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Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the those who go through it you need to err to the side of caution and allow the FDA do its job and demand some investigation be done so the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on the medications. Researchers found that participants taking this drug for a year, lost weight within four weeks and have kept the extra weight off through the 56 weeks of the study. Contrave is often a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more potent and safer. Combo-pilling is the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that at the time of right now there are not any long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise hypertension and heartbeat, and mustn't be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. Acamprosate also actively works to eliminate the wish to drink by eliminating the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is not yet obtainable in the United States. While it has become widely studied in Europe the actual chemical reason that it works is still unknown. It is belief that it disturbs receptors within the brain which process glutamate, which essentially alters the way ones body reacts to alcohol intake. Several of the European research shows a lot of promise with Acamprosate because some of the patients had a virtually double rate of success for staying sober.

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